BACK
TO
TOP
Browse A-Z
Print-Friendly
Bookmarks
bookmarks-menu

Sarcoidosis

Sarcoidosis is a disease in which inflammation occurs in the lymph nodes, lungs, liver, eyes, skin, and/or other tissues.

Causes

The exact cause of sarcoidosis is unknown. What is known is that when a person has the disease, tiny clumps of abnormal tissue (granulomas) form in certain organs of the body. Granulomas are clusters of immune cells.

The disease can affect almost any organ. It most commonly affects the lungs.

Health experts think that having certain genes makes it more likely for a person to develop sarcoidosis. Things that may trigger the disease include infections with bacteria or viruses. Contact with dust or chemicals may also be triggers.

The disease is more common in African Americans and White people of Scandinavian heritage. More women than men have the disease.

The disease often begins between ages 20 and 40. Sarcoidosis is rare in young children.

A person with a close blood relative who has sarcoidosis is nearly 5 times as likely to develop the condition.

Symptoms

There may be no symptoms. When symptoms do occur, they can involve almost any body part or organ system.

Almost all people affected by sarcoidosis have lung or chest symptoms:

Symptoms of general discomfort may include:

Skin symptoms may include:

Nervous system symptoms may include:

Eye symptoms may include:

Other symptoms of this disease may include:

  • Dry mouth
  • Fainting spells, if the heart is involved
  • Nosebleed
  • Swelling in the upper part of the abdomen
  • Liver disease
  • Swelling of the legs if heart and lungs are involved
  • Abnormal heart rhythm if the heart is involved

Exams and Tests

The health care provider will perform a physical examination and ask about the symptoms.

Different imaging tests may help diagnose sarcoidosis:

To diagnose this condition, a biopsy is needed. A biopsy of the lung using bronchoscopy is usually done. Biopsies of other body tissues may also be done.

The following lab tests may be done:

Treatment

Sarcoidosis symptoms will often get better without treatment, especially if there are only small lung abnormalities.

If the eyes, heart, nervous system, or lungs are affected, corticosteroids are usually prescribed. This medicine may need to be taken for 1 to 2 years.

Medicines that suppress the immune system are sometimes also needed.

In rare cases, people with very severe heart or lung damage (end-stage disease) may need an organ transplant.

With sarcoidosis that affects the heart, an implantable cardioverter-defibrillator (ICD) may be needed to treat heart rhythm problems.

Outlook (Prognosis)

Many people with sarcoidosis are not seriously ill, and get better without treatment. Up to half of all people with the disease get better in 3 years without treatment. People whose lungs are affected may develop lung damage.

Overall the death rate from sarcoidosis is less than 5%. Causes of death include:

  • Bleeding from the lung tissue
  • Heart damage, leading to heart failure and abnormal heart rhythms
  • Lung scarring (pulmonary fibrosis)

Possible Complications

Sarcoidosis may lead to these health problems:

When to Contact a Medical Professional

Contact your provider promptly if you have:

Open References

References

Iannuzzi MC. Sarcoidosis. Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 89.

Judson MA, Koth LL, Baughman RP. Sarcoidosis. In: Broaddus VC, Ernst JD, King TE, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 7th ed. Philadelphia, PA: Elsevier; 2022:chap 93.

Soto-Gomez N, Peters JI, Nambiar AM. Diagnosis and management of sarcoidosis. Am Fam Physician. 2016;93(10):840-848. PMID: 27175719 pubmed.ncbi.nlm.nih.gov/27175719/.

  • Sarcoid, stage I - chest X-ray

    Sarcoid, stage I - chest X-ray - illustration

    Sarcoid is primarily a lung (pulmonary) disease. In the early stages, a chest film may show enlargement of lymph nodes in the center of the chest near the heart (mediastinum).

    Sarcoid, stage I - chest X-ray

    illustration

  • Sarcoid, stage II - chest X-ray

    Sarcoid, stage II - chest X-ray - illustration

    Sarcoid causes damage to the lung tissue that heals by scarring. The film shows a diffuse milky and granular appearance in the normally dark lung areas. This individual has marked decrease in lung function.

    Sarcoid, stage II - chest X-ray

    illustration

  • Sarcoid, stage IV - chest x-ray

    Sarcoid, stage IV - chest x-ray - illustration

    This film shows advanced sarcoid, scarring of the lungs (the light streaking), and cavity formation (the dark areas in the upper right side of the picture).

    Sarcoid, stage IV - chest x-ray

    illustration

  • Sarcoid - close-up of the skin lesions

    Sarcoid - close-up of the skin lesions - illustration

    Sarcoid - close-up of the skin lesions. 20 to 25 percent of individuals with sarcoidosis have skin manifestations as seen in this picture. The extent of the skin manifestations is difficult to predict, but the most common are red papules that are translucent as seen here.

    Sarcoid - close-up of the skin lesions

    illustration

  • Erythema nodosum associated with sarcoidosis

    Erythema nodosum associated with sarcoidosis - illustration

    This picture shows reddish-purple, hard (indurated), painful nodules (erythema nodosum) that occur most commonly on the shins. These lesions may be anywhere on the body and may be associated with tuberculosis (TB), sarcoidosis, coccidioidomycosis, systemic lupus erythematosis (SLE), fungal infections, or in response to medications.

    Erythema nodosum associated with sarcoidosis

    illustration

  • Sarcoidosis - close-up

    Sarcoidosis - close-up - illustration

    Typical sarcoid lesions consist of red, raised lesions (papules) and patches (plaques) with minimal surrounding skin change.

    Sarcoidosis - close-up

    illustration

  • Sarcoidosis on the elbow

    Sarcoidosis on the elbow - illustration

    These lesions of sarcoidosis are located on the elbow and are red, elevated patches (plaques). The cause of sarcoidosis remains unknown.

    Sarcoidosis on the elbow

    illustration

  • Sarcoidosis on the nose and forehead

    Sarcoidosis on the nose and forehead - illustration

    These are sarcoid lesions on the face. These lesions often appear in scars, as is seen in this photograph.

    Sarcoidosis on the nose and forehead

    illustration

  • Respiratory system

    Respiratory system - illustration

    Air is breathed in through the nasal passageways, travels through the trachea and bronchi to the lungs.

    Respiratory system

    illustration

  • Sarcoid, stage I - chest X-ray

    Sarcoid, stage I - chest X-ray - illustration

    Sarcoid is primarily a lung (pulmonary) disease. In the early stages, a chest film may show enlargement of lymph nodes in the center of the chest near the heart (mediastinum).

    Sarcoid, stage I - chest X-ray

    illustration

  • Sarcoid, stage II - chest X-ray

    Sarcoid, stage II - chest X-ray - illustration

    Sarcoid causes damage to the lung tissue that heals by scarring. The film shows a diffuse milky and granular appearance in the normally dark lung areas. This individual has marked decrease in lung function.

    Sarcoid, stage II - chest X-ray

    illustration

  • Sarcoid, stage IV - chest x-ray

    Sarcoid, stage IV - chest x-ray - illustration

    This film shows advanced sarcoid, scarring of the lungs (the light streaking), and cavity formation (the dark areas in the upper right side of the picture).

    Sarcoid, stage IV - chest x-ray

    illustration

  • Sarcoid - close-up of the skin lesions

    Sarcoid - close-up of the skin lesions - illustration

    Sarcoid - close-up of the skin lesions. 20 to 25 percent of individuals with sarcoidosis have skin manifestations as seen in this picture. The extent of the skin manifestations is difficult to predict, but the most common are red papules that are translucent as seen here.

    Sarcoid - close-up of the skin lesions

    illustration

  • Erythema nodosum associated with sarcoidosis

    Erythema nodosum associated with sarcoidosis - illustration

    This picture shows reddish-purple, hard (indurated), painful nodules (erythema nodosum) that occur most commonly on the shins. These lesions may be anywhere on the body and may be associated with tuberculosis (TB), sarcoidosis, coccidioidomycosis, systemic lupus erythematosis (SLE), fungal infections, or in response to medications.

    Erythema nodosum associated with sarcoidosis

    illustration

  • Sarcoidosis - close-up

    Sarcoidosis - close-up - illustration

    Typical sarcoid lesions consist of red, raised lesions (papules) and patches (plaques) with minimal surrounding skin change.

    Sarcoidosis - close-up

    illustration

  • Sarcoidosis on the elbow

    Sarcoidosis on the elbow - illustration

    These lesions of sarcoidosis are located on the elbow and are red, elevated patches (plaques). The cause of sarcoidosis remains unknown.

    Sarcoidosis on the elbow

    illustration

  • Sarcoidosis on the nose and forehead

    Sarcoidosis on the nose and forehead - illustration

    These are sarcoid lesions on the face. These lesions often appear in scars, as is seen in this photograph.

    Sarcoidosis on the nose and forehead

    illustration

  • Respiratory system

    Respiratory system - illustration

    Air is breathed in through the nasal passageways, travels through the trachea and bronchi to the lungs.

    Respiratory system

    illustration

 

Review Date: 5/3/2023

Reviewed By: Denis Hadjiliadis, MD, MHS, Paul F. Harron, Jr. Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
© 1997- adam.comAll rights reserved.

 
 
 

 

 

A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.
Content is best viewed in IE9 or above, Firefox and Google Chrome browser.