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Thyroid cancer - medullary carcinoma

Thyroid - medullary carcinoma; Cancer - thyroid (medullary carcinoma); MTC; Thyroid nodule - medullary

Medullary carcinoma of the thyroid is cancer of the thyroid gland that starts in cells that release a hormone called calcitonin. These cells are called "C" cells. The thyroid gland is located inside the front of your lower neck.

Causes

The cause of medullary carcinoma of the thyroid (MTC) is unknown. MTC is very rare. It can occur in children and adults.

Unlike other types of thyroid cancer, MTC is less likely to be caused by radiation therapy to the neck given to treat other cancers during childhood.

There are two forms of MTC:

  • Sporadic MTC, which does not run in families. Most MTCs are sporadic. This form mainly affects older adults.
  • Hereditary MTC, which runs in families.

You have an increased risk for this type of cancer if you have:

Other types of thyroid cancer include:

Symptoms

MTC often begins as a small lump (nodule) in the thyroid gland. There also may be lymph node swelling in the neck. As a result, symptoms may include:

  • Swelling of the neck
  • Hoarseness
  • Breathing problems due to narrowing of airways
  • Cough
  • Cough with blood
  • Diarrhea due to high calcitonin level

Exams and Tests

Your health care provider will perform a physical exam and ask about your symptoms and medical history.

Tests that may be used to diagnose MTC include:

People with MTC should be checked for certain other tumors, especially pheochromocytoma and parathyroid tumors and parathyroid tumors.

Treatment

Treatment involves surgery to remove the thyroid gland and surrounding lymph nodes. Because this is an uncommon tumor, surgery should be performed by a surgeon who is familiar with this type of cancer and experienced with the operation required.

Further treatment will depend on your calcitonin levels. A rise in calcitonin levels again may indicate new growth of the cancer.

  • Chemotherapy and radiation do not work very well for this type of cancer.
  • Radiation is used in some people after surgery.
  • Newer targeted therapies may reduce tumor growth also. Your provider can tell you more about these, if needed.

Near relatives of persons diagnosed with hereditary forms of MTC are at increased risk of this cancer and should discuss with their providers.

Support Groups

You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.

Outlook (Prognosis)

Most people with MTC live at least 5 years after diagnosis, depending upon the stage of the cancer. The 10-year survival rate is 65%.

Possible Complications

Complications may include:

  • Cancer spreads to other areas of the body
  • Parathyroid glands are accidentally removed during surgery

When to Contact a Medical Professional

Contact your provider if you have symptoms of MTC.

Prevention

Prevention may not be possible. But, being aware of your risk factors, especially your family history, may allow for early diagnosis and treatment. For people who have a very strong family history of MTC, the option to remove the thyroid gland may be recommended. You should carefully discuss this option with a doctor who is very familiar with the disease.

Open References

References

Kim M, Kim BH. Current guidelines for management of medullary thyroid carcinoma. Endocrinol Metab. 2021;36(3):514-524. PMID: 34154310 pubmed.ncbi.nlm.nih.gov/34154310/.

National Cancer Institute website. Thyroid cancer treatment (PDQ) - health professional version. www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq. Updated April 11, 2024. Accessed May 3, 2024.

Pearce EN, Hollenberg AN. Thyroid. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 207.

Suh I, Sosa JA. Thyroid. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 21st ed. St Louis, MO: Elsevier; 2022:chap 37.

  • Thyroid cancer - CT scan

    Thyroid cancer - CT scan - illustration

    This CT scan of the upper chest (thorax) shows a malignant thyroid tumor (cancer). The dark area around the trachea (marked by the white U-shaped tip of the respiratory tube) is an area where normal tissue has been eroded and died (necrosis) as a result of tumor growth.

    Thyroid cancer - CT scan

    illustration

  • Thyroid gland

    Thyroid gland - illustration

    The thyroid gland, a part of the endocrine (hormone) system, plays a major role in regulating the body's metabolism.

    Thyroid gland

    illustration

  • Thyroid cancer - CT scan

    Thyroid cancer - CT scan - illustration

    This CT scan of the upper chest (thorax) shows a malignant thyroid tumor (cancer). The dark area around the trachea (marked by the white U-shaped tip of the respiratory tube) is an area where normal tissue has been eroded and died (necrosis) as a result of tumor growth.

    Thyroid cancer - CT scan

    illustration

  • Thyroid gland

    Thyroid gland - illustration

    The thyroid gland, a part of the endocrine (hormone) system, plays a major role in regulating the body's metabolism.

    Thyroid gland

    illustration

 

Review Date: 3/31/2024

Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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