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Addison disease

Adrenocortical hypofunction; Chronic adrenocortical insufficiency; Primary adrenal insufficiency; Addison's disease

Addison disease is a disorder that causes the adrenal glands to not produce enough hormones.

Causes

The adrenal glands are small hormone-releasing organs located on top of each kidney. They are made up of an outer portion, called the cortex, and an inner portion, called the medulla.

The cortex produces 3 hormones:

  • Glucocorticoid hormones (such as cortisol) maintain sugar (glucose) control, blood pressure, decrease (suppress) immune response, and help the body respond to stress.
  • Mineralocorticoid hormones (such as aldosterone) regulate sodium, water and potassium balance.
  • Sex hormones, androgens (male) and estrogens (female), affect sexual development and sex drive.

Addison disease results from damage to the adrenal cortex. The damage causes the cortex to produce hormone levels that are too low.

This damage may be caused by the following:

  • The immune system mistakenly attacking the adrenal glands (autoimmune disease)
  • Infections such as tuberculosis, HIV, or fungal infections
  • Hemorrhage into the adrenal glands
  • Tumors

Risk factors for the autoimmune type of Addison disease include other autoimmune diseases:

Certain rare genetic defects may also cause adrenal insufficiency.

Symptoms

Symptoms of Addison disease may include any of the following:

  • Abdominal pain
  • Chronic diarrhea, nausea, and vomiting
  • Darkening of the skin
  • Dehydration
  • Dizziness when standing up
  • Low-grade fever
  • Low blood sugar
  • Low blood pressure, especially with a change in body position
  • Extreme weakness, fatigue, and slow, sluggish movement
  • Darker skin on the inside of the cheeks and lips (buccal mucosa)
  • Salt craving (eating food with a lot of added salt)
  • Weight loss with reduced appetite

Symptoms may not be present all the time. Many people have some or all of these symptoms when they have an infection or other stress on the body. Other times, they have no symptoms.

Exams and Tests

Your health care provider will perform a physical exam and ask about the symptoms.

Blood tests will likely be ordered and may show:

Additional laboratory tests may be ordered.

Other tests may include:

Treatment

Treatment with replacement corticosteroids and mineralocorticoids will control the symptoms of this disease. These medicines usually need to be taken for life.

Never skip doses of your medicine for this condition because life-threatening reactions may occur.

Your provider may tell you to increase your dosage for a short time because of:

  • Infection
  • Injury
  • Stress
  • Surgery

During an extreme form of adrenal insufficiency, called adrenal crisis, you must inject hydrocortisone right away. Treatment for low blood pressure is usually needed as well.

Some people with Addison disease (or family members) are taught to give themselves an emergency injection of hydrocortisone during stressful situations. Always carry medical ID (card, bracelet, or necklace) that says you have adrenal insufficiency. The ID should also say the type of medicine and dosage you need in case of an emergency.

Outlook (Prognosis)

With hormone therapy, many people with Addison disease are able to lead a nearly normal life.

Possible Complications

Complications can occur if you take too little or too much adrenal hormone.

When to Contact a Medical Professional

Contact your provider if:

  • You are unable to keep your medicine down due to vomiting.
  • You have stress such as infection, injury, trauma, or dehydration. You may need to have your medicine adjusted.
  • Your weight increases over time.
  • Your ankles begin to swell.
  • You develop new symptoms.
  • While taking treatment, you develop signs of a disorder called Cushing syndrome

If you have symptoms of adrenal crisis, give yourself an emergency injection of your prescribed medicine. If it is not available, go to the nearest emergency room or call 911 or the local emergency number.

Symptoms of adrenal crisis include:

  • Abdominal pain
  • Difficulty breathing
  • Dizziness or lightheadedness
  • Low blood pressure
  • Reduced level of consciousness
Open References

References

Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2016;101(2):364-389. PMID: PMC4880116 www.ncbi.nlm.nih.gov/pmc/articles/PMC4880116/.

Newell-Price JDC, Auchus RJ. The adrenal cortex. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 15.

Nieman LK. Adrenal cortex. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 208.

  • Endocrine glands

    Endocrine glands - illustration

    Endocrine glands release hormones (chemical messengers) into the bloodstream to be transported to various organs and tissues throughout the body. For instance, the pancreas secretes insulin, which allows the body to regulate levels of sugar in the blood. The thyroid gets instructions from the pituitary to secrete hormones which determine the rate of metabolism in the body (the more hormone in the bloodstream, the faster the chemical activity; the less hormone, the slower the activity).

    Endocrine glands

    illustration

  • Endocrine glands

    Endocrine glands - illustration

    Endocrine glands release hormones (chemical messengers) into the bloodstream to be transported to various organs and tissues throughout the body. For instance, the pancreas secretes insulin, which allows the body to regulate levels of sugar in the blood. The thyroid gets instructions from the pituitary to secrete hormones which determine the rate of metabolism in the body (the more hormone in the bloodstream, the faster the chemical activity; the less hormone, the slower the activity).

    Endocrine glands

    illustration

Tests for Addison disease

 
 

Review Date: 5/12/2023

Reviewed By: Sandeep K. Dhaliwal, MD, board-certified in Diabetes, Endocrinology, and Metabolism, Springfield, VA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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