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Pneumocystis jirovecii pneumonia

Pneumocystis pneumonia; Pneumocystosis; PCP; Pneumocystis carinii; PJP pneumonia

Pneumocystis jirovecii pneumonia is a fungal infection of the lungs. The disease used to be called Pneumocystis carinii or PCP pneumonia.

Causes

This type of pneumonia is caused by the fungus Pneumocystis jirovecii. This fungus is common in the environment and rarely causes illness in healthy people.

However, it can cause a lung infection in people with a weakened immune system due to:

Pneumocystis jirovecii was a rare infection before the AIDS epidemic. Before the use of preventive antibiotics for the condition, most people in the United States with advanced AIDS developed this infection.

Symptoms

Pneumocystis pneumonia in people with AIDS usually develops slowly over days to weeks or even months, and is less severe. People with pneumocystis pneumonia who do not have AIDS usually get sick faster and are more severely ill.

Symptoms include:

  • Cough, often mild and dry
  • Fever
  • Rapid breathing
  • Shortness of breath, especially with activity (exertion)

Exams and Tests

Your health care provider will examine you and ask about your symptoms.

Tests that may be ordered include:

Treatment

Anti-infection medicines can be given by mouth (orally) or through a vein (intravenously), depending on how severe the illness is.

People with low oxygen levels and moderate to severe disease are often prescribed corticosteroids as well.

Outlook (Prognosis)

Pneumocystis pneumonia can be life threatening. It can cause respiratory failure that can lead to death. People with this condition need early and effective treatment. For moderate to severe pneumocystis pneumonia in people with HIV/AIDS, the short term use of corticosteroids has decreased the incidence of death.

Possible Complications

Complications that may result include:

When to Contact a Medical Professional

If you have a weakened immune system due to AIDS, cancer, transplantation, or corticosteroid use, contact your provider if you develop a cough, fever, or shortness of breath.

Prevention

Preventive therapy is recommended for:

  • People with HIV/AIDS who have CD4 counts below 200 cells/microliter or 200 cells/cubic millimeter
  • Bone marrow transplant recipients
  • Organ transplant recipients
  • People who take long-term, high-dose corticosteroids
  • People who have had previous episodes of this infection
  • People who take long-term immunomodulatory medicines
Open References

References

Kovacs JA. Pneumocystis pneumonia. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 313.

Miller RF Walzer PD, Smulian AG. Pneumocystis species. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 269.

  • Lungs

    Lungs - illustration

    The major features of the lungs include the bronchi, the bronchioles and the alveoli. The alveoli are the microscopic blood vessel-lined sacks in which oxygen and carbon dioxide gas are exchanged.

    Lungs

    illustration

  • AIDS

    AIDS - illustration

    AIDS (acquired immune deficiency syndrome) is caused by HIV (human immunodeficiency virus), and is a syndrome that leaves the body vulnerable to a host of life-threatening illnesses. There is no cure for AIDS, but treatment with antiviral medicine can suppress symptoms. AIDS is universally fatal, in large part due to the proliferation of opportunistic infections.

    AIDS

    illustration

  • Pneumocystosis

    Pneumocystosis - illustration

    Pneumocystosis is an infection of the lungs caused by the microorganism Pneumocystis carinii. Pneumocystosis is almost exclusively seen in individuals whose immune systems have been compromised by AIDS or chemotherapy. Pneumocystosis is usually a terminal event in AIDS patients.

    Pneumocystosis

    illustration

  • Lungs

    Lungs - illustration

    The major features of the lungs include the bronchi, the bronchioles and the alveoli. The alveoli are the microscopic blood vessel-lined sacks in which oxygen and carbon dioxide gas are exchanged.

    Lungs

    illustration

  • AIDS

    AIDS - illustration

    AIDS (acquired immune deficiency syndrome) is caused by HIV (human immunodeficiency virus), and is a syndrome that leaves the body vulnerable to a host of life-threatening illnesses. There is no cure for AIDS, but treatment with antiviral medicine can suppress symptoms. AIDS is universally fatal, in large part due to the proliferation of opportunistic infections.

    AIDS

    illustration

  • Pneumocystosis

    Pneumocystosis - illustration

    Pneumocystosis is an infection of the lungs caused by the microorganism Pneumocystis carinii. Pneumocystosis is almost exclusively seen in individuals whose immune systems have been compromised by AIDS or chemotherapy. Pneumocystosis is usually a terminal event in AIDS patients.

    Pneumocystosis

    illustration

 

Review Date: 12/31/2023

Reviewed By: Jatin M. Vyas, MD, PhD, Associate Professor in Medicine, Harvard Medical School; Associate in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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