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Myoglobin urine test

Urine myoglobin; Heart attack - myoglobin urine test; Myositis - myoglobin urine test; Rhabdomyolysis - myoglobin urine test

The myoglobin urine test is done to detect the presence of myoglobin in urine.

Myoglobin can also be measured with a blood test.

How the Test is Performed

A clean-catch urine sample is needed. The clean-catch method is used to prevent germs from the penis or vagina from getting into a urine sample. To collect your urine, the health care provider may give you a special clean-catch kit that contains a cleansing solution and sterile wipes. Follow instructions exactly so that the results are accurate.

How the Test will Feel

The test involves only normal urination, which should cause no discomfort.

Why the Test is Performed

Myoglobin is a protein in heart and skeletal muscles. When you exercise, your muscles use up available oxygen. Myoglobin has oxygen attached to it, which provides extra oxygen for the muscles to keep up a high level of activity for a longer period.

When muscle is damaged, myoglobin in muscle cells is released into the bloodstream. The kidneys help remove myoglobin from the blood into the urine. When the level of myoglobin is too high, it can damage the kidneys.

This test is ordered when your provider suspects you have muscle damage, such as damage to the heart or skeletal muscle. It may also be ordered if you have acute kidney failure without any clear cause.

Normal Results

A normal urine sample does not have myoglobin. A normal result is sometimes reported as negative.

Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results.

What Abnormal Results Mean

Abnormal results may be due to:

  • Heart attack
  • Malignant hyperthermia (very rare)
  • Disorder that causes muscle weakness and loss of muscle tissue (muscular dystrophy)
  • Breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood (rhabdomyolysis)
  • Skeletal muscle inflammation (myositis)
  • Skeletal muscle ischemia (oxygen deficiency)
  • Skeletal muscle trauma

Risks

There are no risks with this test.

Open References

References

Nagaraju K, Aggarwal R, Lundberg IE. Inflammatory diseases of muscle and other myopathies. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelly's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 90.

Selcen D. Muscle diseases. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 393.

  • Urine sample

    Urine sample - illustration

    A clean-catch urine sample is performed by collecting the sample of urine in midstream. Men or boys should wipe clean the head of the penis. Women or girls need to wash the area between the lips of the vagina with soapy water and rinse well. A small amount of urine should initially fall into the toilet bowl before it is collected (this clears the urethra of contaminants). Then, in a clean container, catch about 1 to 2 ounces of urine and remove the container from the urine stream. The container is then given to the health care provider.

    Urine sample

    illustration

  • Female urinary tract

    Female urinary tract - illustration

    The female and male urinary tracts are relatively the same except for the length of the urethra.

    Female urinary tract

    illustration

  • Male urinary tract

    Male urinary tract - illustration

    The male and female urinary tracts are relatively the same except for the length of the urethra.

    Male urinary tract

    illustration

  • Urine sample

    Urine sample - illustration

    A clean-catch urine sample is performed by collecting the sample of urine in midstream. Men or boys should wipe clean the head of the penis. Women or girls need to wash the area between the lips of the vagina with soapy water and rinse well. A small amount of urine should initially fall into the toilet bowl before it is collected (this clears the urethra of contaminants). Then, in a clean container, catch about 1 to 2 ounces of urine and remove the container from the urine stream. The container is then given to the health care provider.

    Urine sample

    illustration

  • Female urinary tract

    Female urinary tract - illustration

    The female and male urinary tracts are relatively the same except for the length of the urethra.

    Female urinary tract

    illustration

  • Male urinary tract

    Male urinary tract - illustration

    The male and female urinary tracts are relatively the same except for the length of the urethra.

    Male urinary tract

    illustration

Tests for Myoglobin urine test

 
 

Review Date: 2/28/2023

Reviewed By: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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