Methylergonovine (By injection)

Methylergonovine (meth-il-er-goe-NOE-veen)

Prevents bleeding from the uterus that can happen after childbirth. This medicine is an ergot alkaloid.

Brand Name(s):

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given as a shot into a muscle or into a vein. This medicine is usually given after delivery of the placenta or during the second stage of labor.
• Your doctor may also prescribe methylergonovine tablets for you to take. Be sure to follow all your doctor's instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how methylergonovine works. Tell your doctor if you are using any of the following:
  • Chlorzoxazone, cilostazol, clarithromycin, clotrimazole, fluconazole, fluvoxamine, itraconazole, ketoconazole, nefazodone, nevirapine, ranitidine, rifampin, saquinavir, troleandomycin, voriconazole
  • Blood pressure medicine (including beta blockers)
  • Medicine to treat chest pain
  • Medicine to treat HIV infection (including indinavir, nelfinavir, ritonavir)
  • Other ergot medicine (including dihydroergotamine, ergotamine)
• Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

• Your unborn baby could be harmed if you use this medicine before you go into labor. This medicine may cause contractions of the uterus and cause you to give birth early.
• Do not breastfeed during treatment with this medicine and for at least 12 hours after the last dose.
• Tell your doctor if you have kidney disease, liver disease, heart or blood vessel disease, diabetes, high cholesterol, overweight, or if you smoke .
• This medicine may increase your chance of heart problems or a heart attack.
• Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Chest pain or discomfort, fast or uneven heartbeat, sweating, trouble breathing, or pain in the arm, back, or jaw
• Decrease in how much or how often you urinate
• Lightheadedness or fainting
• Seizures
• Severe headache, blurred vision
• Tingling of the fingers, toes, or feet

If you notice these less serious side effects, talk with your doctor:

• Diarrhea, nausea, vomiting, stomach pain
• Pain, itching, burning, swelling, or a lump under your skin where the needle is placed or shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 8/4/2025