Erenumab-aooe (By injection)

Erenumab-aooe (e-REN-ue-mab - aooe)

Prevents migraine headaches.

Brand Name(s):

Aimovig 140MG, Aimovig 70MG

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. It is usually given in the stomach, thighs, or upper arm.
• A nurse or other health provider will give you this medicine.
• You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
• This medicine is available in 2 forms: a prefilled syringe and a prefilled Sure Click® autoinjector. Before you inject this medicine, always check the label of the device to make sure you have the correct medicine and the correct dose.
• Allow 30 minutes for the medicine to warm up to room temperature. Do not warm it by using a heat source (including hot water, microwave, direct sunlight) or in any other way.
• Check the liquid in the prefilled syringe or autoinjector. It should be clear and colorless to slightly yellow. Do not use it if it is cloudy, discolored, or has particles in it. Do not shake. Do not use it if it is cracked, broken, or has been dropped.
• You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not inject into skin areas that are raised, thick, red, scaly skin patch or lesion, or areas with scars or stretch marks.
• Prefilled syringe:
  • Wash your hands with soap and water before and after using this medicine.
  • Do not grab the plunger rod or gray needle cap. Do not remove the gray needle cap until you are ready to inject.
  • Pull the gray needle cap straight out. Do not leave the cap off for more than 5 minutes. Do not twist or bend the gray needle cap.
  • Pinch the skin firmly. Insert the syringe into your skin at 45 to 90 degree angle. Place your finger on the plunger rod. Push the plunger rod all the way down until the syringe stops moving.
• Prefilled Sure Click® autoinjector:
  • Wash your hands with soap and water before and after using this medicine.
  • Pull the cap straight off. Do not twist, bend, or wiggle the cap to pull it off. Never put the cap back on. Do not put your finger inside the safety guard.
  • Stretch or pinch the skin. Place the safety guard straight against the skin. Make sure you can see the window.
  • Firmly push the autoinjector down until the safety guard stops moving. Hold the autoinjector down, do not lift. Keep pushing the autoinjector down and press the start button to start the injection. You may hear or feel a "click". The window will start to turn yellow.
  • The injection may take up to 15 seconds to complete. When the window is fully yellow, the injection is complete. The safety guard locks around the needle.
• Use a new needle and syringe each time you inject your medicine.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Missed dose: If you miss a dose of this medicine, use it as soon as you can. Then, continue to use it each month from the date of your last dose.
• If you store this medicine at home, keep it in the refrigerator. Do not freeze. Keep the medicine in its original carton. You may store it at room temperature for up to 7 days after removing it from the refrigerator. Throw away any unused medicine kept at room temperature after 7 days.
• Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how erenumab-aooe works. Tell your doctor if you are using medicines that decrease bowel movement.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have high blood pressure or a history of blood vessel disease (including Raynaud's phenomenon).
• This medicine may cause the following problems:
  • Severe constipation
  • High blood pressure
  • Raynaud's phenomenon, a blood circulation problem in the fingers or toes
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blurred vision, dizziness, nervousness, headache, pounding in the ears, slow or fast heartbeat
• Constipation
• Sores, coldness, numbness, or color changes on your fingers or toes

If you notice these less serious side effects, talk with your doctor:

• Pain, itching, burning, swelling, or a lump under your skin where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 6/4/2025