Crinecerfont (By mouth)

Crinecerfont (kri-ne-SER-font)

Controls androgen levels in patients with classic congenital adrenal hyperplasia (CAH).

Brand Name(s):

Crenessity

When This Medicine Should Not Be Used:

How to Use This Medicine:

Capsule, Liquid

• Your doctor will tell you how much medicine to use. Do not use more than directed.
• It is best to take this medicine with food or milk.
• Swallow the capsule whole with liquid.
• If you are unable to swallow the capsule whole, you may use the oral liquid:
  • Remove the child-resistant cap by pressing it down while twisting it counterclockwise.
  • While holding the bottle firmly, use the thumb on your other hand to push the press-in bottle adapter in to the bottle as far as it will go. Do not remove the adapter after it has been inserted.
  • Insert the tip of the oral syringe into the press-in bottle adapter, then turn the bottle upside down.
  • Slowly pull the plunger of the syringe until the plunger lines up with the prescribed dose. Turn the bottle and syringe right side up. Hold the syringe from the middle, then remove it from the bottle. Do not touch the plunger to avoid oral liquid from coming out of the syringe.
  • Place the tip of the oral syringe inside your mouth and point it towards the inside of the cheek. Slowly push the plunger all the way down to give the full dose. Put the child-resistant cap back on with the press-in bottle adapter still inserted.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Missed dose: If you miss a dose, take it as soon as possible (even if it is almost time for your next dose), and then go back to your regular dosing schedule.
• Capsule: Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
• Oral liquid:
  • Store the oral liquid in its original container in an upright position.
  • Store unopened oral liquid in the refrigerator. Do not freeze. You may also store opened oral liquid in the refrigerator or at room temperature for up to 30 days. Throw away unused oral liquid after 30 days of first opening the bottle.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how crinecerfont works. Tell your doctor if you are using ketoconazole or rifampin.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, infection, severe injury, shock, trauma, or a planned surgery.
• This medicine may increase your risk of adrenal gland problems. Keep using your corticosteroid medicine during treatment.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Darkening of the skin, cold feeling, weakness, tiredness, nausea, vomiting, weight loss

If you notice these less serious side effects, talk with your doctor:

• Back, muscle, or joint pain
• Bloody nose, stuffy or runny nose
• Headache, dizziness
• Stomach pain, decreased appetite

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 3/4/2025