Donidalorsen (By injection)

Donidalorsen (doe-nid-a-LOR-sen)

Prevents hereditary angioedema (HAE) attacks.

Brand Name(s):

Dawnzera

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
• A nurse or other health provider will give you this medicine.
• You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
• You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not inject within 2 inches of the belly button, into scars, damaged skin, or into skin areas that are bruised, red, tender, or hard.
• Allow 30 minutes for the medicine to warm up to room temperature. Do not warm it by using a heat source (including hot water, microwave) or in any other way.
• Check the liquid in the autoinjector. It should be clear and colorless to yellow. Do not use it if it is cloudy, discolored, or has particles in it. Do not use it if it looks damaged or the clear cap is missing or not attached.
• Autoinjector:
  • Wash your hands with soap and water before and after using this medicine.
  • Do not remove the cap until you are ready to inject.
  • Pull the cap straight off. Do not twist the clear cap. Do not recap. Do not push the orange needle shield against the hand or finger.
  • Place the autoinjector at a 90 degree angle against your skin. Push firmly and hold the autoinjector straight against your skin. You will hear a "click" which means the injection has started. You will hear a second "click" after the first one. Keep pressing down for 10 seconds to make sure you get the full dose. Make sure the orange plunger completely fills the window.
• Use a new needle and syringe each time you inject your medicine.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
• If you store this medicine at home, keep it in the refrigerator. Do not freeze. Keep it in its original container. Protect from light. Do not freeze. If needed, you may store the autoinjector at room temperature for up to 6 weeks. Throw away unused medicine within 6 weeks.
• Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or liver disease.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Change in how much or how often you urinate, lower back or side pain, trouble urinating
• Fever, chills, cough, runny or stuffy nose, sore throat, body aches
• Pain, redness, or burning under your skin where the shot is given

If you notice these less serious side effects, talk with your doctor:

• Stomach discomfort

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 10/4/2025